NEnglJMed;:-January14,DOI:10./NEJMoaBACKGROUND
Tuberculousmeningitisisoftenlethal.Earlyantituberculosistreatmentandadjunctivetreatmentwithglucocorticoidsimprovesurvival,butnearlyonethirdofpatientswiththeconditionstilldie.WehypothesizedthatintensifiedantituberculosistreatmentwouldenhancethekillingofintracerebralMycobacteriumtuberculosisorganismsanddecreasetherateofdeathamongpatients.
METHODSWeperformedarandomized,double-blind,placebo-controlledtrialinvolvinghumanimmunodeficiencyvirus(HIV)–infectedadultsandHIV-uninfectedadultswithaclinicaldiagnosisoftuberculousmeningitiswhowereadmittedtooneoftwoVietnamesehospitals.We白癜风能治愈么新疆白癜风医院
